Subunit exchange of hemoglobin α2β2 tetramer

• Subunit exchange between PEGylated and native Hbs

Fig. 1 Dimeric αβ subunit exchange between bis-PEGylated Hb (bis-PEG-Hb) and native Hb
through association-dissociation equilibrium of α2β2 tetramers.

Title: Analysis of Dimeric αβ Subunit Exchange between PEGylated and Native Hemoglobins (α2β2 Tetramer) in an Equilibrated State by Intramolecular ββ-Cross-Linking
Biomacromolecules 19(8), 3412-3420 (2018)
HDL:10564/3868 in institutional repository (the version post-peer review)

• Ring-opening polymerization via the association-dissociation equilibrium of Hb units

Fig. 2 Ring-opening polymerization of cyclic Hb monomer and subsequernt crosslinking.

Title: Ring-Opening Polymerization of Hemoglobin
Biomacromolecules 20(4), 1592-1602 (2019) >> Journal Cover Image (Supplementary)
HDL:10564/3869 in institutional repository (the version post-peer review)


Title: Entropy-Driven Supramolecular Ring-Opening Polymerization of a Cyclic Hemoglobin Monomer for Constructing a Hemoglobin-PEG Alternating Polymer with Structural Regularity
Biomacromolecules 32(5), 1944-1954 (2021).
HDL:10564/3870 in institutional repository (the version post-peer review)

• Rheological properties of Hb-introduced hydrogels

Fig. 3 Synthesis of Hb-introduced physical and chemical gels.

Title: Change in viscoelasticity of the hemoglobin-introduced supramolecular polymer hydrogel in response to pH, temperature, and oxygen partial pressure.
Biomacromolecules 26(8), 5212-5223 (2025). (open access)

Title: Rheological Properties of Hemoglobin-Based Physical and Chemical Gels, and Their Hybrid.
ACS Omega 11(1), 2194-2205 (2026). (open access)

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